The Laboratory of Computational Genomics aims to create and use new software tools to explore the unfolding world of genomes. Our tools aim to integrate, analyze, and visualize the output of high throughput molecular biology experiments in the context of complete genome sequence data. Projects in the laboratory focus on the automated annotation of eukaryotic and microbial genome sequence data (genomes, chromosomes, contigs, and cDNA clones), the semi-automated annotation of gene expression data, and the integration of gene expression and genome sequence analysis. We apply these tools to specific biological questions in collaboration with experimental biologists and to the problem of structural genomics target selection.

Sea Urchin Genome Published
The genome of the California Purple Sea Urchin, Strongylocentrotus purpuratus, was published on November 10, 2006. Visit the Sea Urchin Genome Project for more information.

Developing systems to extend and expedite genome annotation including areas such as transcription analysis, automated functional annotation of genes and extending links between genes and groups of genes to integrate the gene by gene view into an over-arching genome level view.